The 91探花 is proud to announce that 56 faculty and researchers who completed their work while at 91探花have been named on the list from Clarivate.

The annual list identifies researchers who demonstrated significant influence in their chosen field or fields through the publication of multiple highly cited papers during the last decade. Their names are drawn from the publications that rank in the top 1% by citations for field and publication year in the .

Highly Cited Researchers demonstrate significant and broad influence in their fields of research. The total list includes 7,131 awards from more than 1,300 institutions in 60 countries and regions. This small fraction of the global researcher population contributes disproportionately to extending the frontiers of knowledge and contributing to innovations that make the world healthier, more sustainable and which drive societal impact, according to Clarivate.

The that determines the 鈥渨ho鈥檚 who鈥� of influential researchers is drawn from data and analysis performed by bibliometric experts and data scientists at the Institute for Scientific Information at Clarivate.

The list below includes faculty and researchers whose primary affiliation is with the UW, Fred Hutch Cancer Center, and the Institute for Health Metrics and Evaluation.

Please note: Some of the people on the list are no longer with the 91探花and their current affiliation is noted. This list reflects initial data from Clarivate and may be updated.

Ivan Anishchenko (Vilya)

David Baker

William A. Banks

Gregory N. Bratman

Steven L. Brunton

Guozhong Cao

Ting Cao

Lauren Carter (Gates Medical Research Institute)

Helen Chu

David H. Cobden

Katharine H. D. Crawford

Riza M. Daza

Frank DiMaio

Kristie L. Ebi

Evan E. Eichler

Emmanuela Gakidou

David Ginger

Raphael Gottardo (CHUV)

Alexander L. Greninger

Simon I. Hay

Andrew Hill (Infinimmune)

Eric Huang

Michael C. Jensen (BrainChild)

Neil P.聽 King

C. Dirk Keene

J. Nathan Kutz

Eric H. Larson

Aaron Lyon

Michael J. MacCoss

Brendan MacLean

C. M. Marcus

Julian D. Marshall

Ali Mokdad

Thomas J. Montine (Stanford)

Mohsen Naghavi

Marian L. Neuhouser

Julian D. Olden

Robert W. Palmatier

David Pigott

Hannah A. Pliner (Bristol Myers Squibb)

Ganesh Raghu

Stanley Riddell

Andrea Schietinger (Memorial Sloan Kettering Cancer Center)

Jay Shendure

M. Alejandra Tortorici

Troy R. Torgerson (Allen Institute)

Cole Trapnell

Katherine R. Tuttle

David Veesler

Theo Vos

Alexandra C. Walls (BioNTech SE)

Bryan J. Weiner

Di Xiao

Jie Xiao

Xiaodong Xu

Jihui Yang

The 91探花 is proud to announce that more than 40 faculty and researchers who completed their work while at 91探花have been named on the annual list from Clarivate.

The annual list identifies researchers who demonstrated significant influence in their chosen field or fields through the publication of multiple highly cited papers during the last decade. Their names are drawn from the publications that rank in the top 1% by citations for field and publication year in the Web of Science citation index.

The list of faculty and researchers whose primary affiliation is with the 91探花or with the Institute for Health Metrics and Evaluation who were acknowledged for their work includes:

David Baker

William A. Banks

Gregory N. Bratman

Steven L. Brunton

Guozhong Cao

William A. Catterall

Helen Chu

David H. Cobden

Katharine H.D. Crawford

Riza M. Daza

Frank DiMaio

Evan E. Eichler

Michael Gale Jr.

Raphael Gottardo

Allison J. Greaney

Alexander L. Greninger

Simon I. Hay

Celestia S. Higano

Neil P. King

James B. Leverenz

Charles M. Marcus

Philip Mease

Ali Mokdad

Thomas J. Montine*

Christopher J. L. Murray

Mohsen Naghavi

William S. Noble

Young-Jun Park

David M. Pigott

Stanley Riddell

Andrea Schietinger **

Jay Shendure

M. Alejandra Tortorici

Troy R. Torgerson***

Cole Trapnell

David Veesler

Theo Vos

Alexandra C. Walls****

Bryan J. Weiner

Spencer A. Wood

Sanfeng Wu

Di Xiao

Xiaodong Xu

The that determines the 鈥渨ho鈥檚 who鈥� of influential researchers draws on the data and analysis performed by bibliometric experts and data scientists at the Institute for Scientific Information at Clarivate. It also uses the tallies to identify the countries and research institutions where these scientific elite are based.

The full 2023 Highly Cited Researchers list and executive summary can be found online .

* now is at Stanford University.

** now is at Memorial Sloan Kettering Cancer Center.

*** now is at the Allen Institute.

**** now is at BoiNTech SE.

now is at Princeton University.

The 91探花 is proud to announce that 47 faculty and researchers who completed their work while at 91探花have been named on the annual list from Clarivate.

The highly anticipated annual list identifies researchers who demonstrated significant influence in their chosen field or fields through the publication of multiple highly cited papers during the last decade. Their names are drawn from the publications that rank in the top 1% by citations for field and publication year in the Web of Science citation index.

The list of faculty and researchers who were acknowledged for their work while at 91探花includes:

• David Baker
• Frank DiMaio
• William Sheffler
• Dr. Jay Shendure
• Cole Trapnell
• David Veesler
• Alexandra C. Walls*
• Philip Mease
• Dr. Christopher J. L. Murray
• Dr. Ganesh Raghu
• Dr. Stanley Riddell
• Alejandra Tortorici
• Dr. William A. Banks
• Gregory N. Bratman
• Steven L. Brunton
• Guozhong Cao
• William A. Catterall
• David H. Cobden
• Riza M. Daza
• Dr. E. Patchen Dellinger
• Dr. Janet A. Englund
• E. Erskine
• Michael Gale Jr.
• Raphael Gottardo
• Celestia S. Higano
• Neil P. King
• Ali Mokdad
• William S. Noble
• Julian D. Olden
• L. Patrick
• David L. Smith
• Dr. Piper Meigs Treuting
• Spencer A. Wood
• Jesse R. Zaneveld
• Ning Zheng
• Dr. Hans D. Ochs
• Simon I. Hay
• Evan E. Eichler
• Deborah A. Nickerson**
• John A. Stamatoyannopoulos***
• Dr. Thomas J. Montine****
• Di Xiao
• Xiaodong Xu
• Bryan J. Weiner
• Mohsen Naghavi
• Theo Vos
• David M. Pigott

The that determines the 鈥渨ho鈥檚 who鈥� of influential researchers draws on the data and analysis performed by bibliometric experts and data scientists at the Institute for Scientific Information at Clarivate. It also uses the tallies to identify the countries and research institutions where these scientific elite are based. This year Clarivate partnered with Retraction Watch and extended the qualitative analysis of the Highly Cited Researchers list, addressing increasing concerns over potential misconduct.

The full 2022 Highly Cited Researchers list and executive summary can be found online .

* now is at BioNTech SE.

** on Dec. 24, 2021.

*** now is at Altius.

**** now is at Stanford University.

Seven professors at the 91探花 are among 25 new members of the Washington State Academy of Sciences, according to a . Joining the academy is a recognition of 鈥渢heir outstanding record of scientific and technical achievement, and their willingness to work on behalf of the Academy to bring the best available science to bear on issues within the State of Washington.鈥�

Twenty of the incoming members for 2022 were selected by current WSAS members, while the other five were chosen by virtue of recently joining one of the National Academies.

91探花faculty selected by current Academy members are:

• , the Robert G. and Jean A. Reid Executive Dean of Nursing, 鈥渇or pioneering research in cultural competence, conducting international collaborative research with professionals and family caregivers of older adults with dementia, advancing assessment of cultural awareness and its impact on healthcare, and supporting establishment of UW鈥檚 Center for Global Health Nursing and the first Center for Anti-Racism in Nursing.鈥�
• , the Harry and Catherine Jaynne Boand Endowed Professor of Chemistry, co-associate chair of the Department of Chemistry, and associate vice provost for research cyberinfrastructure, 鈥渇or a body of work that supercharges computational chemistry, including pioneering work in time- dependent electronic structure theory and quantum mechanical techniques,鈥� and 鈥渇or exemplary collaborative efforts, as well as leadership in developing educational pathways for underrepresented minority students in STEM.鈥� Li is also a faculty member in the 91探花Clean Energy Institute and the 91探花Molecular & Engineering Sciences Institute.
• , the Steven and Connie Rogel Endowed Professor of Chemical Engineering, professor of chemistry, and chair of the Department of Chemical Engineering, 鈥渇or pioneering contributions that advanced the frontiers of molecular simulation, impacting the prediction of enzyme activity in ionic liquids, peptide interactions with surfaces and molecular design.鈥� Pfaendtner is also a faculty member in the Clean Energy Institute and the Molecular & Engineering Sciences Institute, as well as a senior data fellow with the 91探花eScience Institute and staff scientist at the Pacific Northwest National Laboratory.
• , the Klaus and Mary Ann Saegebarth Endowed Professor of Chemistry, 鈥渇or pioneering fundamental and applied studies in mass spectrometry, physical chemistry, and newborn screening鈥� as well as 鈥減ropagation of science, science education, and technical expertise contributions to startup companies in Washington state.鈥�
• , the Kyocera Professor in Materials Science & Engineering and vice dean of the College of Engineering, 鈥渇or pioneering contribution to the discovery of new thermoelectric and energy storage materials for clean energy, and for exceptional leadership to promote interdisciplinary collaboration among academia, industry, and national laboratories for creating transformational and sustainable impact for Washington.鈥� Yang is also a faculty member in the Clean Energy Institute and the Molecular & Engineering Sciences Institute.
• Dr. , professor of radiology and director of the 91探花Medicine Image-Guided Bio-Molecular Intervention Laboratory, 鈥渇or work as an internationally prominent physician-scientist in the field of image-guided minimally invasive interventional therapies鈥� and 鈥渇or pioneering contributions and outstanding achievements in developing innovative and cutting-edge medical imaging and interventional radiology for effective management of life-threatening diseases, such as atherosclerotic cardiovascular disease and cancer.鈥�

In addition, Dr. , 91探花professor of genome sciences, investigator with the Howard Hughes Medical Institute and faculty member in the Molecular Engineering & Sciences Institute, was selected by virtue of his election to the National Academy of Sciences 鈥渇or pioneering a variety of genome sequencing and analysis methods, including exome sequencing and its earliest applications to gene discovery for Mendelian disorders and autism; cell-free DNA diagnostics for cancer and reproductive medicine; massively parallel reporter assays; saturation genome editing; whole organism lineage tracing; and massively parallel molecular profiling of single cells.鈥�

New members to the Washington State Academy of Sciences will be formally inducted in September.

Four faculty members at the 91探花 have been elected to the National Academy of Sciences. The new members from the 91探花are:

• , professor and chair of physiology and biophysics
• , professor of microbiology
• Dr. , professor of genome sciences
• James Truman, professor emeritus of biology

They are among 120 new members and 30 international members to the National Academy of Sciences this year. Election 鈥渞ecognizes achievement in science by election to membership, and 鈥� with the National Academy of Engineering and the National Academy of Medicine 鈥� provides science, engineering, and health policy advice to the federal government and other organizations,鈥� according to an May 3 by the academy.

is noted for her research on the neural mechanisms behind learning and remembering. She studies how a system of structures in the brain, including the hippocampus and its surrounding cortical regions, set up new memories and how this system functions during memory retrieval. These structures are the first to be affected in Alzheimer鈥檚 disease. Lesions within these structures are associated with profound memory deficits. Her work may help improve the understanding of what foreshadows the onset Alzheimer鈥檚 and other dementias. She has a particular interest in how the brain maps surroundings, because getting lost in familiar locations is a common early symptom of Alzheimer鈥檚. Buffalo earned her doctoral degree at the University of California, San Diego and did postdoctoral training in neuropsychology at the National Institute of Mental Health. She received the 2011 Troland Research Award for her innovative studies from the National Academy of Sciences.

is known for his research on how bacteria interact with each other in the environment and in our bodies. Much of his work focuses on the battles that occur within communities of bacteria. He examines the arsenals they deploy to attack each other and defend themselves. Among his areas of study are antibacterial toxins that disable target cells in a variety of ways, secretion systems that mediate antagonism between bacteria, and the toxins that virulent bacteria secrete to overcome host defense strategies. His laboratory also studies the densely populated mammalian gut microbiome, where conflict rages among microbes as bacteria compete for resources and struggle to survive. His lab is hoping to harness the antimicrobial tactics of bacteria to develop new therapies for infections and other purposes. Mougous earned his doctoral degree from the University of California, Berkeley. He is a Howard Hughes Medical Institute investigator and a researcher at the 91探花Medicine Institute for Stem Cell and Regenerative Medicine. In 2021, he received the National Institute of Sciences Award in Molecular Biology for his pioneering studies in microbiology.

Dr. 鈥檚 research group has pioneered a variety of genome sequencing and analysis methods, including exome sequencing and its earliest applications to gene discovery for Mendelian disorders and autism; cell-free DNA diagnostics for cancer and reproductive medicine; massively parallel reporter assays; saturation genome editing; whole organism lineage tracing; and massively parallel molecular profiling of single cells. He has received numerous awards, including the 2012 Curt Stern Award from the American Society of Human Genetics, a 2013 National Institutes of Health Director’s Pioneer Award and the 2019 Richard Lounsbery Award from the National Academy of Sciences. Dr. Shendure has been an advisor to the NIH Director, the U.S. Precision Medicine Initiative, the National Human Genome Research Institute, the Chan-Zuckerberg Initiative and the Allen Institutes for Cell Science and Immunology. He received his M.D. and Ph.D. degrees in 2007 from Harvard Medical School, where he trained with geneticist and molecular biologist George Church on advancing DNA sequencing techniques. He is currently an investigator with the Howard Hughes Medical Institute, director of the Allen Discovery Center for Cell Lineage Tracing and scientific director of the Brotman Baty Institute for Precision Medicine.

Truman鈥檚 studies have focused on the genes, hormones and neural architecture underlying insect development and evolution. Early in his career, he identified the key hormone in moths that induces molting, as well as the brain-based circadian rhythms that exert overall control over this process. He later studied regulation of molting in the fruit fly and genes that control metamorphosis in moths. Truman earned a doctoral degree from Harvard University in 1970, where he continued as a Harvard Junior Fellow until joining the 91探花faculty in 1973. He became a full professor in 1978. He retired from the 91探花in 2007 and became a Group Leader at the Howard Hughes Medical Institute鈥檚 Janelia Research Campus, where he studied nervous system metamorphosis in fruit flies. In 2016, Truman returned to the 91探花as a professor emeritus, and today continues to study the evolution and development of insects and crustaceans at the UW鈥檚 Friday Harbor Laboratories. In 1970, he received the American Association for the Advancement of Science鈥檚 Newcomb Cleveland Research Prize and was a Guggenheim Fellow in 1986. Truman was elected to the American Academy of Arts and Sciences in 2009.

With this year鈥檚 addition, the National Academy of Sciences now has 2,512 active members and 517 nonvoting international members, who hold citizenship outside of the U.S.

, a 91探花professor of environmental and occupational health sciences in the School of Public Health, is recognized “for studies of effects of oxidative stress on adverse health effects associated with exposure to air pollution and environmental chemicals.”

Kavanagh investigates adverse health effects of exposure to air pollution and chemicals to understand the mechanisms by which they cause toxicity and inflammation. He also studies the role of antioxidants and is developing more accurate in vitro models to test chemicals for potential risk to humans.

Kavanagh directs the 91探花 and the 91探花 and co-directs the . He is also an adjunct professor in the departments of Medicine and Pathology.

, professor of genome sciences at the 91探花School of Medicine, was selected for 鈥渢he development of technologies and methods to advance genetics and genomics, with a focus on technologies that impact the understanding of human diseases.鈥�

Shendure leads a research group that advances rapid, less-expensive, next-generation DNA sequencing. He is also a pioneer in that looks at the protein-coding regions of an individual鈥檚 genome. Exome sequencing is now being used by groups worldwide to find gene variants for single-gene disorders and for disease traits influenced by multiple genes.

Shendure directs the , established last year to combine the scientific strengths in precision medicine of 91探花Medicine, Fred Hutchinson Cancer Research Center and Seattle Children’s. He is also a Howard Hughes Medical Institute investigator and directs the .

The advance was reported Nov. 3 in by several 91探花 scientists led by Dr. Jay Shendure, associate professor of genome Sciences.

Existing technologies can quickly produce billions of 鈥渟hort reads鈥� of segments of DNA at very low cost.聽 Various approaches are currently used to put the pieces together to see how DNA segments line up to form larger stretches of the genetic code.

However, current methods produce a highly fragmented genome assembly, lacking long-range information about what sequences are near what other sequences, making further biological analysis difficult.

鈥淕enome science has remained remarkably distant from routinely assembling genomes to the standards set by the Human Genome Project,鈥� said the researchers. 聽They noted that the Human Genome Project tapped into many different techniques to achieve its end result.聽 Many of these are too expensive, technically difficult, and impractical for large-scale initiatives such as the Genome 10K Project, which aims to sequence and assemble the genomes of 10,000 vertebrate species.

Members of the Shendure lab that developed what they hope will be a more scalable strategy were Joshua N. Burton, Andrew Adey, Rupali P. Patwardhan, Ruolan Qiu, and Jacob O. Kitzman.

To more completely assemble genomes, they tapped into a technology called Hi-C, which measures the three-dimensional architecture and physical territories of chromosomes within the nuclei of cells. Hi-C maps the physical interactions between regions of the chromosomes in a genome, including contact within a chromosome and with other chromosomes. 聽The results indicate which regions tend to occur near each other within three-dimensional space in a cell鈥檚 nucleus.

The researchers speculated that this interaction data, because it offers clues about the position of and distances between various regions of the chromosome, might reveal how DNA sequences are grouped and lined up along entire chromosomes. 聽聽They wondered if the interaction data could show them which regions of the genome are near each other on each chromosome.

Their investigation of this possibility led them to create what they named LACHESIS (an acronym for 鈥渓igating adjacent chromatin enables scaffolding in situ鈥�), and also the Fate that measures the thread of destiny.

The map of physical interactions generated by Hi-C was interpreted by the LACHESIS computational program to assign, order and orient genomic sequences into their correct position along chromosomes, including DNA positioned close to the centromere, the 鈥減inch waist鈥� gap in the chromosome shape.

The researchers combined their new approach with other cheap and widely used sequencing methods to generate chromosome-scale assemblies of the human, mouse and fruit fly genomes. The researchers were able to cluster nearly all scaffolds — collections of short DNA segments whose position relative to each other is unknown — into groups that corresponded to individual chromosomes.

They then ordered and oriented the scaffolds assigned to each chromosome group, and validated their results by comparing them to the high-quality reference genomes for these species that were generated by the Human Genome Project. In the case of human genome, they achieved 98 percent accuracy in assigning tens of thousands of sequences of contiguous DNA to chromosome groups and 99 percent accuracy in ordering and orienting these sequences within chromosome groups.

鈥淲e think the method may fundamentally change how we approach the assembly of new genomes with next-generation sequencing technologies,鈥� noted Shendure.

While he and his team cite many areas in which the computational and experimental methods can be improved, the approach is an important step in his lab鈥檚 long-term goal to facilitate the assembly, for a variety of species, of low-cost, high-quality genomes that meet the rigorous standards set by the Human Genome Project.

The research was supported by grants HG006283 and T32HG000035 from the National Human Genome Research Institute, and graduate research fellowships from the National Science Foundation.

The research program encourages scientists to pursue creative and innovative ideas about biomedical and behavioral research with the aim of addressing today’s major challenges in these fields. Total funding for the awards is about $123 million and comes from the National Institutes of Health Common Fund, and a number of institutes and centers.

The 2013 91探花recipients:

, assistant professor of microbiology, studies how head-on collisions between DNA-code reading machineries accelerate evolution. Her work on harmless bacteria shows that they appear to speed up their evolution by positioning genes along the route of expected traffic jams in DNA-encoding. This tactic might also be imitated by harmful bacteria to adjust to conditions in the body, thereby strengthening their virulence or causing persistent infections. Similar methods for speeding up evolution during environmental stress are likely to occur in other living creatures as well. With her New Innovator Award, Merrikh will look at the clashes that take place when a DNA strand is being read to create a new set of genes during cell reproduction or to produce a protein. The work will explain natural mechanisms of gene repair and mutation, and provide insights into evolution and adaptation.

, associate professor of genome sciences, and his lab have created rapid, cost-effective methods to study subtle differences in DNA codes among people. His group is interested in how these genetic variations might affect susceptibility or resistance to disease, or response to treatment. Testing for such genetic variations is increasingly helping to guide and personalize health care. However, patients often carry difficult-to-interpret variants in clinically relevant genes such as those linked to breast and ovarian cancer. Shendure’s Pioneer Award will support the search for new approaches to estimate the consequences of all possible variants of clinically relevant genes. He hopes this will improve the interpretation of human genome sequences in diverse clinical and research settings.

, assistant professor of bioengineering, works on creating new organ-specific microenvironments for both regenerative medicine and therapeutic development. Zheng and her group are developing聽3-D systems in vitro that display the complex architecture of bone marrow and function to generate blood cells. These systems could allow for the preclinical testing for therapies to increase blood cell counts in diseases where they are low. This system also has the potential to be scaled up to generate enough blood cells for transfusions. Zheng’s research project is called “A microfluidic bone marrow niche for the study of hematopoiesis.”