  {"id":42959,"date":"2022-06-30T10:17:24","date_gmt":"2022-06-30T17:17:24","guid":{"rendered":"https:\/\/www.washington.edu\/research\/?page_id=42959"},"modified":"2025-11-19T13:50:24","modified_gmt":"2025-11-19T21:50:24","slug":"steps-in-the-single-irb-review-process-follow-ons","status":"publish","type":"page","link":"https:\/\/www.washington.edu\/research\/hsd\/single-irb\/uw-irb-as-a-single-irb\/steps-in-the-single-irb-review-process-follow-ons\/","title":{"rendered":"Steps in the Single IRB Review Process for Follow-on Submissions"},"content":{"rendered":"<p><img decoding=\"async\" class=\"WP-PrintIcon\" src=\"https:\/\/www.washington.edu\/research\/wp-content\/plugins\/wp-print\/images\/printer_famfamfam.gif\"  alt=\"Print\" title=\"Print\" style=\"border: 2px;\">&nbsp;<a href=\"https:\/\/www.washington.edu\/research\/hsd\/single-irb\/uw-irb-as-a-single-irb\/steps-in-the-single-irb-review-process-follow-ons\/print\/\" title=\"Print\" rel=\"nofollow\" target=\"_blank\">Print<\/a><\/p>\n<p>This page describes<\/p>\n<ul style=\"margin-left: 20px;\">\n<li>How the  91探花IRB reviews the ongoing activities of single IRB applications and the activities of relying institutions<\/li>\n<li>The steps to obtain sIRB review from the  91探花IRB<\/li>\n<li>Who is responsible for completing what tasks during the review process<\/li>\n<\/ul>\n<div class=\"table-of-contents\">\n<h3 id=\"toc\">Contents<\/h3>\n<ul class=\"list-unstyled\">\n<li><a href=\"#overview\">Overview of responsibilities<\/a><\/li>\n<li><a href=\"#cr\">Continuing review<\/a><\/li>\n<li><a href=\"#studymod\">Study-level modifications<\/a><\/li>\n<li><a href=\"#sitemod\">Site-level modifications<\/a><\/li>\n<li><a href=\"#rni\">Reports of new information<\/a><\/li>\n<li><a href=\"#closure\">Site or study closure<\/a><\/li>\n<li><a href=\"#related\">Related materials<\/a><\/li>\n<li><a href=\"#version\">Version information<\/a><\/li>\n<\/ul>\n<\/div>\n<h2 id=\"overview\">Overview of responsibilities<\/h2>\n<p>Relying institution Study Teams are responsible for following  91探花IRB\u2019s <a href=\"https:\/\/www.washington.edu\/research\/policies\/?type=&amp;topic=&amp;owner=HSD\">policies, procedures and guidance<\/a> as long as the  91探花IRB is overseeing the activities at the institution. This includes, but is not limited to:<\/p>\n<ul style=\"margin-left: 20px;\">\n<li>conducting the research in accordance with the initial IRB approval<\/li>\n<li>obtaining IRB approval prior to implementing any changes to the research<\/li>\n<li>obtaining continuing approval from the IRB when applicable<\/li>\n<li>reporting new information that may impact the IRB\u2019s review<\/li>\n<li>complying with any corrective action plans required by the IRB<\/li>\n<li>complying with a request for audit by the IRB<\/li>\n<\/ul>\n<p>Relying institution Study Teams are also responsible for following their institution\u2019s policies and procedures regarding relying on the  91探花IRB review, which may include obtaining other reviews and sign-offs and delivering IRB review outcome documents to their institution.<\/p>\n<p>HSD\u2019s Zipline system is only accessible by members of the  91探花Study Team who have a  91探花NetID. This means that relying institutions cannot submit materials directly to the IRB. Instead, the  91探花Study Team will need to collect submission materials from relying institutions and submit them to the IRB in Zipline. Additionally, the  91探花Study Team is responsible for delivering all IRB communications and outcome documents to the relying institution study teams.<\/p>\n<p>Successfully conducting multi-institutional research under sIRB review requires careful planning. HSD strongly recommends that study teams develop clear plans for communication among study sites and with the IRB. For more information about the typical communication responsibilities for sIRB, consult the <a href=\"https:\/\/smartirb.org\/wp-content\/uploads\/Communication-Plan.pdf\">Communication Plan for SMART IRB<\/a>.<\/p>\n<div align=\"right\"><a href=\"#toc\">Back to Table of Contents<\/a><\/div>\n<h2 id=\"cr\">Continuing review<\/h2>\n<p>For sIRB applications with an approval period, the approval period applies across all relying institutions. There is no separate approval period for each site. The  91探花Study Team is responsible for communicating this approval period and any changes or lapses in approval to relying institution study teams. In the case of a lapse in approval, all relying institution study teams are responsible for halting activities with human subjects according to the <strong><a href=\"https:\/\/www.washington.edu\/research\/policies\/sop-irb-review-2\/\">SOP IRB Review<\/a><\/strong>.<\/p>\n<p>sIRB applications with an approval period are required to obtain continuing review according to the <strong><a href=\"https:\/\/www.washington.edu\/research\/policies\/sop-irb-review-2\/\">SOP IRB Review<\/a><\/strong>.<\/p>\n<p>The  91探花Study Team is responsible for:<\/p>\n<ul style=\"margin-left: 20px;\">\n<li>Collecting the necessary information from all relying institutions in order to complete the continuing review report<\/li>\n<li>Preparing and <a href=\"https:\/\/www.washington.edu\/research\/hsd\/training\/zipline-online-help-library\/researcher-submission-guide\/continuing-review-and-closure\/\">submitting<\/a> the continuing review report on behalf of all relying institutions<\/li>\n<li>Delivering IRB communications and any outcome documents to all relying institution study teams<\/li>\n<\/ul>\n<p>The relying institution study team is responsible for:<\/p>\n<ul style=\"margin-left: 20px;\">\n<li>Communicating any site-level information to the  91探花study team for inclusion in the continuing review report<\/li>\n<li>Responding to any requests for additional information from the IRB as requested through the  91探花Study Team<\/li>\n<li>Delivering any outcome documents to their IRB or HRPP office as required under their local policies<\/li>\n<\/ul>\n<p>HSD strongly recommends that studies with multiple relying institutions develop a plan ahead of time for how they will coordinate the sharing of this information between relying sites and the  91探花Study Team.<\/p>\n<div align=\"right\"><a href=\"#toc\">Back to Table of Contents<\/a><\/div>\n<h2 id=\"studymod\">Study-level modifications<\/h2>\n<p>All changes to the approved research, with a few exceptions described in the <a href=\"https:\/\/www.washington.edu\/research\/policies\/sop-irb-review-2\/\">SOP IRB Review<\/a>, must be approved by the IRB prior to implementation.<\/p>\n<p>The  91探花Study Team is responsible for identifying the need to submit a study-level modification and for <a href=\"https:\/\/www.washington.edu\/research\/hsd\/training\/zipline-online-help-library\/researcher-submission-guide\/study-modifications\/\">submitting the modification in Zipline<\/a>. This may require communicating with the relying institutions in order to collect information about the changes being proposed. The  91探花Study Team is also responsible for responding to any requests for additional information from the IRB and delivering approved materials and outcome documents to the relying institution study teams.<\/p>\n<p>The relying institution study teams are responsible for implementing the changes to the research as applicable to their institution and delivering any outcome documents from study-level modifications to their IRB or HRPP office as required under their local policies.<\/p>\n<p style=\"padding-left: 30px;\"><strong>Considerations when submitting study level modifications:<\/strong><\/p>\n<p style=\"padding-left: 30px;\">Whether the study-level changes may implicate changes to site-level documents. For example, if there is a major change to study procedures or risks that must then be described in each of the site-specific consent forms. In this case, both a study level modification and a site level modification will be required. HSD reviewers may assist study teams in identifying whether or not site-level modifications may be required in these circumstances, however the  91探花Study Team remains responsible for identifying this need.<\/p>\n<div align=\"right\"><a href=\"#toc\">Back to Table of Contents<\/a><\/div>\n<h2 id=\"sitemod\">Site-level modifications<\/h2>\n<p>All changes to the information provided by relying institution study teams and approved by the IRB must be approved by the IRB prior to implementation.<\/p>\n<p>The relying institution study team is responsible for identifying the need to submit a site-level modification and for providing revised information to the  91探花Study Team for submission to the IRB.<\/p>\n<p>The  91探花Study Team is responsible for <a href=\"https:\/\/www.washington.edu\/research\/hsd\/training\/zipline-online-help-library\/researcher-submission-guide\/managing-multi-site-studies\/#modifications\">submitting the modification in Zipline<\/a>, responding to any requests for additional information from the IRB (which may require communication with relying institutions), and for delivering approved materials and outcome documents to the relying institution study teams.<\/p>\n<p>The relying institution study teams are responsible for implementing the changes to the research at their institution and delivering any outcome documents from site-level modifications to their IRB or HRPP office as required under their local policies.<\/p>\n<p>When reviewing any site-level modifications, the  91探花IRB will refer to the Institutional Profile provided by the relying institution in order to determine if there are any additional local context considerations (e.g., laws or consent requirements provided by the institution) that apply to the changes. If the  91探花IRB is unable to understand how the local context information applies to the changes, it will request that the relying institution study team contact their institution\u2019s IRB or HRPP for guidance prior to approving the changes.<\/p>\n<div align=\"right\"><a href=\"#toc\">Back to Table of Contents<\/a><\/div>\n<h2 id=\"rni\">Reports of new information<\/h2>\n<p>The  91探花Study Team is responsible for identifying and reporting any new information across the overall study that meets the <a href=\"https:\/\/www.washington.edu\/research\/hsd\/study-activities\/report-events-and-new-information\/guide-to-reporting-new-information\/\"> 91探花requirements for reporting new information<\/a>.<\/p>\n<p>Relying institution study teams are responsible for identifying and reporting any new information at their site that meets <a href=\"https:\/\/www.washington.edu\/research\/policies\/relying-sites-reporting-of-new-information\/\"> 91探花requirements for reporting new information from relying institutions<\/a>. They are responsible for promptly communicating this information to the  91探花study team for reporting to the IRB.<\/p>\n<p>The  91探花Study Team is responsible for <a href=\"https:\/\/www.washington.edu\/research\/hsd\/training\/zipline-online-help-library\/researcher-submission-guide\/reports-of-new-information\/\">submitting any reports in Zipline<\/a> on behalf of the overall study or an individual relying institution and for delivering IRB communications and outcome documents to all impacted relying study teams. The relying study teams are responsible for delivering any outcome documents to their institution\u2019s IRB or HRPP office according to their local policies.<\/p>\n<p>If the new information is determined to be serious or continuing non-compliance or results in a suspension or termination of study activities, the  91探花will communicate this outcome to the  91探花PI, the site PI and any impacted relying institution\u2019s IRB or HRPP office according to the terms of the applicable reliance agreement.<\/p>\n<div align=\"right\"><a href=\"#toc\">Back to Table of Contents<\/a><\/div>\n<h2 id=\"closure\">Site or study closure<\/h2>\n<p>HSD does not require that relying sites be closed in Zipline upon the cessation of site activities, however Individual relying sites can be closed when the activities of the employees or agents of the relying institution are no longer considered research with human subjects.<\/p>\n<p>The overall study can be closed when all research with human subjects has been completed across  91探花and all relying sites, including any coordinating centers as described in the <a href=\"https:\/\/www.washington.edu\/research\/policies\/sop-irb-review-2\/\">SOP IRB Review<\/a>.<\/p>\n<p>The  91探花Study Team is responsible for <a href=\"https:\/\/www.washington.edu\/research\/hsd\/training\/zipline-online-help-library\/researcher-submission-guide\/continuing-review-and-closure\/\">submitting all closure requests to the  91探花IRB<\/a> on behalf of the overall study and all relying site study teams and for delivering all outcome documents to the relying site study teams. Relying site study teams are responsible for providing any information required by the  91探花IRB through the  91探花Study Team and for delivering outcome documents to their IRB or HRPP according to their local policies.<\/p>\n<div align=\"right\"><a href=\"#toc\">Back to Table of Contents<\/a><\/div>\n<h2 id=\"related\">Related Materials<\/h2>\n<p><a href=\"https:\/\/www.washington.edu\/research\/policies\/relying-sites-reporting-of-new-information\/\">RELYING SITES Reporting of New Information<\/a><br \/>\n<a href=\"https:\/\/www.washington.edu\/research\/hsd\/training\/zipline-online-help-library\/researcher-submission-guide\/continuing-review-and-closure\/\">RESEARCHER GUIDE Continuing Review and Closure<\/a><br \/>\n<a href=\"https:\/\/www.washington.edu\/research\/hsd\/training\/zipline-online-help-library\/researcher-submission-guide\/managing-multi-site-studies\/#modifications\">RESEARCHER GUIDE Multi-site Modifications<\/a><br \/>\n<a href=\"https:\/\/www.washington.edu\/research\/hsd\/training\/zipline-online-help-library\/researcher-submission-guide\/reports-of-new-information\/\">RESEARCHER GUIDE Reports of New Information<\/a><br \/>\n<a href=\"https:\/\/www.washington.edu\/research\/hsd\/training\/zipline-online-help-library\/researcher-submission-guide\/study-modifications\/\">RESEARCHER GUIDE Study Modifications<\/a><br \/>\n<a href=\"https:\/\/www.washington.edu\/research\/policies\/sop-irb-review-2\/\">SOP IRB Review<\/a><br \/>\n<a href=\"https:\/\/www.washington.edu\/research\/hsd\/study-activities\/report-events-and-new-information\/guide-to-reporting-new-information\/\">WEBPAGE Guide to Reporting New Information<\/a><\/p>\n<div align=\"right\"><a href=\"#toc\">Back to Table of Contents<\/a><\/div>\n<h2 id=\"version\">Version Information<\/h2>\n<p>Open the accordion below for version changes to this guidance.<\/p>\n<div class=\"accordion \" id=\"accordion\">\n<div class=\"screen-reader-text\"><\/div>\n<div class=\"card\">\n<div class=\"card-header\" id=\"accordion-header\">\n<h3 class=\"mb-0\"><button class=\"btn btn-link\" type=\"button\" data-toggle=\"collapse\" data-target=\"#collapse\" aria-expanded=\"false\" aria-controls=\"collapse\"><span class=\"btn-text\">Version History<\/span><span class=\"arrow-box\"><span class=\"arrow\"><\/span><\/span><\/button><\/h3>\n<\/div>\n<div id=\"collapse\" class=\"collapse \" aria-labelledby=\"collapse\" data-parent=\"#accordion\" role=\"region\">\n<table>\n<tbody>\n<tr>\n<th style=\"background-color: #4b2e83; color: #ffffff; text-align: center;\">Version Number<\/th>\n<th style=\"background-color: #4b2e83; color: #ffffff; text-align: center;\">Posted Date<\/th>\n<th style=\"background-color: #4b2e83; color: #ffffff; text-align: center;\">Implementation Date<\/th>\n<th style=\"background-color: #4b2e83; color: #ffffff; text-align: center;\">Change Notes<\/th>\n<\/tr>\n<tr>\n<td>1.2<\/td>\n<td>10.30.2025<\/td>\n<td>10.30.2025<\/td>\n<td>Update SMART IRB link<\/td>\n<\/tr>\n<tr>\n<td>1.1<\/td>\n<td>02.08.2024<\/td>\n<td>02.08.2024<\/td>\n<td>Revised for DEI language, minor revisions<\/td>\n<\/tr>\n<tr>\n<td>1.0<\/td>\n<td>06.30.2022<\/td>\n<td>06.30.2022<\/td>\n<td>Newly posted webpage<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<\/div>\n<\/div>\n<p><strong>Keywords<\/strong>: Internal reliance; Multi-site; Single IRB<\/p>\n","protected":false},"excerpt":{"rendered":"<p>This page describes How the  91探花IRB reviews the ongoing activities of single IRB applications and the activities of relying institutions The steps to obtain sIRB&#8230;<\/p>\n","protected":false},"author":158,"featured_media":0,"parent":32661,"menu_order":1,"comment_status":"closed","ping_status":"closed","template":"templates\/page-builder-units-small-hero.php","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-42959","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.1.1 - 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