Brian M. Iritani, D.V.M., Ph.D.
Vice Chair of Academic Affairs
D.V.M., Washington State University 1988
Ph.D., Immunology, 91探花 1997
Clinical Residency, Lab Animal Medicine, 91探花 1996
Research Post-doctoral Fellow, Fred Hutchinson Cancer Research Center 1999
P: 206-221-3932
F: 206-685-3006
E: biritani@uw.edu
Research, Service, and Training Interests
Dr. Iritani is Vice Chair of Academic Affairs.听 His major clinical interests include small animal medicine and surgery.听 He is currently a Senior Clinical Veterinarian, Director of Surgery, Co-Director of Training Programs, Director of Clerkship Training for Veterinary Students.听 He is a member of the Fred Hutchinson Cancer Center Consortium, Nutrition and Obesity Research Center (NORC), Diabetes and Endocrine Research Center (DERC), Solid tumor and translational research team (STTR), Molecular and Cellular Biology听(MCB) Graduate Program, Initiative for Maximizing Student Diversity (IMSD).听 Dr. Iritani serves on numerous NIH Study Sections in Basic Immunology and is on the Editorial Review Boards for听Comparative Medicine听补苍诲听JAALAS.
The Iritani lab studies the normal functions of oncoproteins and other signaling molecules in the development and function of immune cells, and how when dysregulated, aberrant expression or activity can result in immunodeficiency diseases or cancer.听 Among the oncoproteins the Iritani lab studies include the Ras GTPases, Raf kinase, and the Myc family of transcriptional regulators. More recently the Iritani lab has been utilizing murine models to understand how loss-of-function variants in the genes encoding the metabolic regulator Fnip1 and the actin regulatory protein Hem1 result in Inborn Errors of Immunity (IEI) in children.
Selected Publications
Lymphocyte Signaling
Iritani, B.M., Delrow, J., Grandori, C., Klacking, M., Gomez, I., Carlos, L.S., and Eisenman, R.N. (2002) EMBO J, 21(18) 4820-4830.
Habib, T., Park, H., Tsang, M., de Alboran, I., Nicks, A., Wilson, L., Knoepfler, P., Andrews, S., Rawlings., D., Eisenman, R.N., and听 Iritani, B.M.听 (2007)听 The Journal of Cell Biology, 179(4)717-731.
听 Cancer Price, L.M, Treuting,听 P., Zeng, W., Tsang, M., Bielefeldt-Ohmann, H., and B.M. Iritani听 (2006) Research, 66(2) 828-38.
Gallo, E., Winslow, M.M., Cante-Barrett, K., Radermacher, A.N., Ho, L., McGinnis, L.M., Iritani, B.M., Neilson, J.R., and Crabtree, G.R. (2007)听 Nature, 450(29)731-736.
Fnip1 and Inborn Errors of Immunity
Park, H., Staehling-Hampton, K., Tsang, M., Appleby, M., Brunkow, M.E., Margineantu, D., Hockenbery, D.M., Habib, T., Liggitt, H.D., Carlson, G., and B.M. Iritani (2012).听听 Immunity, May 25;36(5):769-81. Epub 2012 May 17.
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Park, H., Tsang, M.,听Iritani, BM*,听补苍诲听MJ Bevan*听(2014).听Proceedings of the National Academy of Sciences, May 13;111(19):7066-71. doi: 10.1073/pnas.1406473111. Epub 2014 Apr 30. PMID: 24785397.听 *听co-corresponding authors
听Reyes, NL., Banks, GL., Tsang, M., Margineantu, D., Gu, H., Djokovic, D., Chan, J., Torres, M., Liggitt, HD., Hirenallur-S., DK., Hockenbery, DM., Raftery, D., and B.M. Iritani (2015).听 Proceedings of the National Academy of Sciences, Jan 13;112(2):424-9. doi: 10.1073/pnas.1413021112. Epub 2014 Dec 29. PMID: 25548157.
Ramirez-Komo, J.A.,听 Iwata, T., Park, H., Tsang, M., Kang, J., Cui, K., Kwong, W., James, R.G., Baba, M., Schmidt, L.S., and听B.M. Iritani听(2019).听The Journal of Immunology. Dec 1;203(11):2899-2908. doi: 10.4049/jimmunol.1900395. Epub 2019 Nov 1.
Centini, R., Tsang, M., Iwata, T., Park, H., Delrow, J., Margineantu, D., Iritani, B.M., Gu, H., Liggitt, HD., Kang, J., Kang, L., Hockenbery, DM., Raftery, D., and B.M. Iritani (2018). PlosOne.听 Jun 13;13(6):e0197973.
Brian Iritani (2021).听Blood听137(4):436-437.
Hem1 and Inborn Errors of Immunity
听Park,H., Staehling-Hampton, K., Brunkow, M.E., Habib, T., Appleby, M., Zhang,Y., Ramsdell, F., Freie, B., Tsang, M., Liggitt, H.D., Carlson, G., Frevert, C., and B.M. Iritani (2008).听听 The Journal of Experimental Medicine, 205(12)2899-913.
Lauren A. Peters, Jacqueline Perrigoue, Arthur Mortha, Alina Iuga, Won-min Song, Eric M. Neiman , Sean Llewyllan, Brian A. Kidd, Shannon Telesco, Aleksandar Stojmirovic, Jocelyn Sendecki, Shameer Khader, Riccardo Miotta, Ke Hao, Bojan Losic ,Hardik Shah, Yongzhong Zhao, Antonio Di Narzo, Minghui Wang,听 Jeremiah Faith, Miriam Merad, Joel T. Dudley, Andrew Kasarskis, Carrie Brodmerkel, Mark Curran, Anuk Das, Joshua R. Friedman, Yoshinori Fukui, Mary Beth Humphrey,听Brian M. Iritani,听et al (2017)听Nature Genetics,听online Sept 11, 2017 doi:10.1038/ng.3947听听
Suwankitwat. N., Libby, S., Liggitt, HD., Avalos, A., Ruddell, A., Rosch, JW, Park,听H., and听B. M. Iritani听(2021).听The Journal of Experimental Medicine. Apr 5;218(4):e20200472. doi: 10.1084/jem.20200472.
Avalos,听A., Teitsort, J., Suwankitwat,听N., Jackson, S., Woods. J, Christodoulou, A., Morrill, C., Liggitt, HD, Zhu, C., Li, QZ., Bui., K., Park,H., and听B.M. Iritani听(2022).听The听Journal of Clinical Investigation Insight,听May 9;7(9):e153597.doi10.1172/jci.insight.153595. PMID:3553195
听 听 Christodoulou, A., Tsai, J., Suwankitwat., N., Anderson, A., and B.M. Iritani (2024).听 Frontiers in Immunology, Volume 15 – 2024